Vol: 37 Page: 77

Authors:
Zofia Hanusz
Marek Lipiec
Monika Krajewska

Title:
 Relative potency of two preparations with correlated observations

Language: English

Keywords:
relative potency
parallel-line assay
correlated observations
testing a hypothesis
tuberculin-test

Summary:
An estimation method of a test preparation potency in relation to a standard preparation administered to the same experimental units is presented in this paper. The responses for the doses of preparations on the same units are correlated. Moreover, a special structure connected with allocation of the doses on experimental units is considered. A model for the observations and a method of estimation of parameters of the model are presented. A test function for testing a hypothesis about parallelism of regression lines for the standard and test preparations is given. When the hypothesis about parallelism fails to reject, then the formula for the estimator of the relative potency can be defined, which is the main goal of the paper.

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